Indoleamine-2,3-dioxygenase activity induces neutrophil apoptosis
نویسندگان
چکیده
منابع مشابه
Indole peroxygenase activity of indoleamine 2,3-dioxygenase.
The heme enzyme indoleamine 2,3-dioxygenase (IDO) was found to catalyze the oxidation of indole by H(2)O(2), with generation of 2- and 3-oxoindole as the major products. This reaction occurred in the absence of O(2) and reducing agents and was not inhibited by superoxide dismutase or hydroxyl radical scavengers, although it was strongly inhibited by L-Trp. The stoichiometry of the reaction indi...
متن کاملInterferon-induced indoleamine 2,3-dioxygenase activity in human mononuclear phagocytes.
Interferon (IFN)-induced tryptophan degradation, catalyzed by indoleamine 2,3-dioxygenase (IDO), has been shown to mediate antimicrobial activity in epithelial cells. IDO activity has also been augmented in peripheral blood mononuclear cells (PBMC) treated with IFN or interleukin-2 (IL-2). The effector cells in this population have now been further characterized. PBMCs were isolated from normal...
متن کاملLavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC
BACKGROUND Lavender remedies have been used in traditional medicine because of antimicrobial, anti-inflammatory and mood alleviating effects, but underlying molecular mechanisms are not yet fully elucidated. Recently, studies investigating the effects of lavender oil in the context of psychiatric disorders have indicated potent pharmacological properties. Metabolism of tryptophan by indoleamine...
متن کاملSerum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis.
Tuberculosis (TB) continues to be a major health problem, and there are few biomarkers for predicting prognosis. Indoleamine 2,3-dioxygenase (IDO), a potent immunoregulatory molecule, catalyzes the rate-limiting step of tryptophan (Trp) degradation in the kynurenine (Kyn) pathway. An increase in IDO activity determined by the serum Trp/Kyn ratio has been shown to be associated with poor prognos...
متن کاملIndoleamine 2,3-Dioxygenase and Immunological Tolerance during Pregnancy
Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. IFN- γ is the main inducer of this enzyme. IDO acts as an important defense mechanism of innate immunity against pathogens. It also has tumor suppressive activity and prolong...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2011
ISSN: 1364-8535
DOI: 10.1186/cc9628